1990 Topps contains 792 cards and featured a newly designed front that featured 6 different color schemes. The cards fronts have the team name and Topps Logo at the top, above the player photograph. The players name is inside a strip along the bottom. The border is mulicolored. The card backs contain the typical player info and statistics printed in black ink on yellow card board. The backs also contain the montly score-board, which contains players stats from the previous season broken down into months.

Subsets include a tribute to Nolan Ryan, All Stars (AS), Number 1 Draft Picks (No1), Record Breakers (RB) and Turn back the Clock (TBC). This set also includes a special card of the late commission A. Bartlett Giamatti.